Hueng-Sik Choi 사진
Hueng-Sik Choi
Position
Professor
Tel
82-62-530-0503
Fax
82-62-530-0506
E-mail
hsc@chonnam.ac.kr
Nationality
Korean

Contents

Affiliation

Host-Directed Antiviral Research Center, School of Biological Science and Technology, Chonnam National University

Education

- 1981-1985 Department of Biology, Kyung Hee University. Korea(B.S.)

- 1985-1990 Graduate Program in Cell & Developmental Biology Rutgers University& UMDNJ-Medical School. USA (Joint Ph D.)

Major Experience

- 1990-1994 Harvard Medical School,(Post-doctoral fellow)

- 1994-1995 Korea Research Institute of Bioscience and Biotechnology(Foreign Invited scientist)

- 1996-present Hormone Research Center, Chonnam National University (Instructor (1996), Assistant Professor(1998), Associate Professor (2002) and Full Professor (2008))

- 2005-2010 National Research Laboratory: Orphan Nuclear Receptor Laboratory (Principal Investigator)

- 2011-2020 National Creative Research Initiative Center for Nuclear Receptor Signals (Director)

Recent Main Scientific Publication

1. Yang SH. et al. 2023. Structure-based discovery of pyrazolamides as nover ERRr inverse agonists. European Journal of Medicinal Chemistry. 250:115174 (Corresponding author, IF=6.7)

2. Jung YS. et al. 2022. Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRg signaling. Genes & Disease. 10:679-682 (Corresponding author, IF=6.8)

3. Jung YS. et al. 2021. Orphan nuclear receptor ERR gamma regulates hepatic TGF-beta 2 expression and fibrogenic response in CCl4-induced acute liver injury. Archives of Toxicology. 95;3071-3084 (Corresponding author, IF=6.1)

4. Radhakrishnan K. et al. 2021. Orphan nuclear receptor ERR-gamma regulates hepatic FGF23 production in acute kidney in jury. Proc Natl Acad Sci U.S.A . 2118:e2022841118 ( Corresponding author, IF=11.1)

5. Jung YS. et al. 2020. An inverse agonist of estrogen-receptor r regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice. Archives of Toxicology. 94:427-438 (Corresponding author, IF=6.1)

Research Interests

Molecular Endocrinology and Molecular Biology:

Nuclear receptor superfamily is a group of transcription factors regulated by small hydrophobic hormones such as retinoic acid, thyroid hormone, and steroids and also includes a large member of related proteins that do not have known ligands, referred to as orphan nuclear receptors. My major research interests are 1) to investigate the role of orphan nuclear receptor in the regulation of pro- or antiviral host factor gene expression, 2) to screen and characterize novel ligand of orphan nuclear receptor for the control of virus infection and 3) to examine the transcriptional regulation of secretory protein induced by viral infection.